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Quantifying the transcriptional impacts of aneuploidy in human blastocysts

Quantifying the transcriptional impacts of aneuploidy in human blastocysts
The impacts of aneuploidy on gene expression arise via multiple mechanisms of dysregulation. These include not only the direct (i.e., primary) effects of dosage alteration—which are predicted to alter expression in the direction of copy number change—but also complex indirect (i.e., secondary or trans-acting) effects that cascade through regulatory networks, including genes on other chromosomes (1). So-called tertiary effects may additionally arise in response to the phenotypic effects of aneuploidy (e.g., growth defects).
Source: fertstert.org

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