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Preimplantation genetic screening: what is the clinical efficiency?

Preimplantation genetic screening: what is the clinical efficiency?
In the current practice of in vitro fertilization (IVF), preimplantation genetic screening (PGS) is increasingly used to select embryos for transfer. This strategy is designed to maximize the probability of embryo implantation by eliminating embryos with low implantation potential from the cohort. However, PGS is inherently imperfect. Errors may occur during the genetic analysis of the small amount of DNA collected. More importantly, mitotic mosaicism, whose precise incidence in the preimplantation embryo is not known, may lead to sampling errors due to the intentionally limited collection of cells in the trophectoderm biopsy.
Source: fertstert.org

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