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Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Mitochondria play a central role in the regulation of energy metabolism in oocytes and preimplantation embryos, where the number and morphology of mitochondria and mitochondrial DNA (mtDNA) content are tightly regulated. A number of mouse models with mitochondrial dysfunction result in infertility, further confirming the key role of mitochondria in female reproductive function. When cells and organisms detect mitochondrial dysfunction they use response mechanisms directed at recovering salvageable mitochondria and eliminating mitochondria that can no longer be rescued.
Source: fertstert.org

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