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Is in vitro organotypic culture the key to spermatogenesis of human immature testicular tissue?

Is in vitro organotypic culture the key to spermatogenesis of human immature testicular tissue?
Pediatric cancers, though uncommon, are on the rise. As of 2014, there were almost 210,000 male survivors of childhood cancers that were diagnosed from ages 0 to 19 years in the United States. With improved therapies and discovered cures, this number will continue to rise as these patients continue to survive into adulthood (1). Unfortunately, many of these therapies have gonadotoxic effects and challenge these men’s ability to father children. Therefore, it is imperative to address fertility preservation in this patient population before inducing these deleterious effects.
Source: fertstert.org

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