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Human female meiosis checkpoints: how much DNA damage is allowed?

Human female meiosis checkpoints: how much DNA damage is allowed?
The process of oocyte maturation is complex, consisting of sequential events taking place in the cytoplasm and the nucleus of the cell. A mature “competent” oocyte is able to undergo fertilization, reinitiate and complete meiosis, and support the embryo through its first few cellular divisions, until it activates its own genome approximately 3 days after fertilization. Failure of one or more of the delicate events involved in the maturation phase would result in oocytes with cytoplasmic or nuclear defects, and would also affect reproductive success.
Source: fertstert.org

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