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DNA methylation profiling of peripheral blood samples is a promising new approach to screen for male infertility

DNA methylation profiling of peripheral blood samples is a promising new approach to screen for male infertility
Male infertility is a complex, multifactorial, and heterogeneous condition. In ∼15% of couples, infertility results from an identifiable genetic defect. However, in 40% of couples, male infertility is likely to be caused by an unknown genetic abnormality. Consequently, many men evaluated for infertility may not ultimately be diagnosed beyond the phenotype of their infertility, such as azoospermia or maturation arrest. Emerging research into the mechanisms underlying idiopathic male infertility promises new opportunities to provide these men with more specific diagnoses.
Source: fertstert.org

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