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Commentary: when embryos hit the brakes

Commentary: when embryos hit the brakes
If we have gleaned any one general principle from the time-lapse literature with regard to embryo selection, it is this: successful outcome from the transfer of a blastocyst depends somewhat upon it reaching that stage but even more so upon how and when it was reached. The simple visualization of an emerging fluid-filled space in a morula belies the underlying workings of a myriad of ordered molecular interactions. Without a doubt, blastulation is a complex process, with the resulting blastocyst representing the successful derivation of divergent cell lineages, a culmination of an ordered sequence of events that begins with the “start signal,” compaction, in mammalian embryos.

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