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Chromosomal mosaicism in human preimplantation embryos: another fact that cannot be ignored

Chromosomal mosaicism in human preimplantation embryos: another fact that cannot be ignored
In this month’s issue, another publication is presented demonstrating the drawbacks of utilizing technology before we completely understand the biology of the human preimplantation embryo. The debate about the benefits of preimplantation genetic testing of embryos rages on, with proponents extoling the virtues of improved pregnancy rates and outcomes, but glossing over the limitations of current technology. While some of these limitations have been mitigated since the introduction of day-3 embryo biopsies and fluorescence in situ hybridization testing (preimplantation genetic screening [PGS] 1.0), others, like the potentially reduced embryo survival in extended culture and mosaicism due to mitotic errors—which appears to be prevalent in human blastocysts—are unlikely to be overcome.
Source: fertstert.org

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