Bone marrow in the pathophysiology of endometriosis

Bone marrow in the pathophysiology of endometriosis
Endometriosis is a common estrogen-responsive disease. It is critically dependent on active angiogenesis, and therefore new blood vessels are a hallmark of the lesions. Finding ways to block angiogenesis and vasculogenesis may allow for novel methods of endometriosis treatment. Bone marrow−derived endothelial cells widely contribute to vasculogenesis, including in endometriosis and in the uterus during pregnancy (1). Because of their role in the growth of endometriosis lesions and their recruitment to active disease, endothelial progenitor cells present an attractive target for intervention.
Source: fertstert.org