Hypovitaminosis D exacerbates dna damage load and genetic instability in human uterine fibroids which is ameliorated by vitamin D3 treatment

Hypovitaminosis D exacerbates dna damage load and genetic instability in human uterine fibroids which is ameliorated by vitamin D3 treatment
Uterine fibroids (UFs) have higher prevalence in African American (AA) women, along with higher prevalence of hypovitaminosis D. As our group has shown that vitamin D deficiency is risk factor for UF development. Also we have recently demonstrated increased DNA repair defect in UF. Taking all together, we hypothesize that vitamin D3 deficiency exacerbates a DNA damage response (DDR) defect and genetic instability associated with UFs, with enhanced tumor progression and burden. Hence we propose that vitamin D3, through reparation of an impaired DDR, will provide therapeutic benefit against UFs.
Source: fertstert.org